产品货号：
GS4553
中文名称：
重组人GDNF
英文名称：
Recombinant Human Glial Cell-derived Neurotrophic Factor
产品规格：
2μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 30.4kDa,a homodimeric protein consisting of two 135 amino acid non-glycosylated polypeptide chains.
储存条件：冷冻（-20℃）
概述
Glial cell-derived neurotrophic factor is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.It is a founding member of the GDNF family of ligands(GFL)and has been shown to interact with GFRA2 and GDNF family receptor alpha.GDNF(monomer)contains seven conserved cysteine residues,one of which(Cys 101)is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.Rat and human mature GDNF shows 93%sequence identity and have species cross-reactivity.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人GDNF，GDNF, Human
储存条件：冷冻（-20℃）
概述
Glial cell-derived neurotrophic factor is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.It is a founding member of the GDNF family of ligands(GFL)and has been shown to interact with GFRA2 and GDNF family receptor alpha.GDNF(monomer)contains seven conserved cysteine residues,one of which(Cys 101)is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.Rat and human mature GDNF shows 93%sequence identity and have species cross-reactivity.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞97%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 0.1ng/ml,corresponding to a specific activity of>1.0×107 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in 20mMPB,500 mM NaCl,pH 6.4. |
| 内毒素 | Less than 1 EU/μg of rHuGDNF as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI |
相关搜索：重组人GDNF，GDNF, Human